Properties of Collagen Matrix in Bone of Maturing, Growing and Adult rabbits: Effects on Tissue Mechanics

INTRODUCTION During maturation bone undergoes changes in its composition, organization and mechanical properties [1-2]. However, the contribution of the collagen framework on the properties of maturing bone is not well understood. Previous studies in mice and horses showed that the collagen network experiences significant structural modifications during development and maturation [2-3]. Our objective was to assess the biochemical and mechanical development of the collagen matrix in rabbit bone from birth to adult mature age. Mechanical properties of decalcified bone tissue were investigated by tensile mechanical testing and correlated with biochemical analysis of the collagen matrix. These structurecomposition-function interactions are crucial for understanding the development of the organic matrix in bone from young age to adulthood. We hypothesized that the mechanical strength of the collagen network is highly related to its chemical composition, including its enzymatic and non-enzymatic cross-links.